منابع مشابه
Androgen receptor phosphorylation.
Phosphorylation of transcription factors plays an important role in regulation of gene expression. DNA-binding, transactivation activity, and subcellular trafficking of specific transcription factors have been shown to be regulated by phosphorylation/dephosphorylation. Steroid hormone receptors are phospho-proteins, and mutations in phosphorylation sites significantly affect the transactivation...
متن کاملProline-Directed Androgen Receptor Phosphorylation
The androgen receptor (AR) has been identified for decades and mediates essential steroid functions. Like most of biological molecules, AR functional activities are modulated by post-translational modifications. This review is focused on the reported activities and significance of AR phosphorylation, with particular emphasis on proline-directed serine/threonine phosphorylation that occurs predo...
متن کاملPhosphorylation of androgen receptor isoforms.
Phosphorylation of the human AR (androgen receptor) is directly correlated with the appearance of at least three AR isoforms on an SDS/polyacrylamide gel. However, it is still not clear to what extent phosphorylation is involved in the occurrence of isoforms, which sites are phosphorylated and what are the functions of these phosphosites. The human AR was expressed in COS-1 cells and AR phospho...
متن کاملPhosphorylation and activation of androgen receptor by Aurora-A.
Aurora-A kinase is frequently overexpressed/activated in various types of human malignancy, including prostate cancer. In this study, we demonstrate elevated levels of Aurora-A in androgen-refractory LNCaP-RF but not androgen-sensitive LNCaP cells, which prompted us to examine whether Aurora-A regulates the androgen receptor (AR) and whether elevated Aurora-A is involved in androgen-independent...
متن کاملMini-review: androgen receptor phosphorylation in prostate cancer.
Androgen receptor (AR) plays an important role in the tumorigenesis and progression of prostate cancer (PCa), and is the primary therapeutic target for PCa treatment. AR activity can be regulated via phosphorylation at multiple phosphorylation sites within the protein. Modifications by phosphorylation alter AR function, including its cellular localization, stability and transcriptional activity...
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ژورنال
عنوان ژورنال: Annals of the New York Academy of Sciences
سال: 1993
ISSN: 0077-8923,1749-6632
DOI: 10.1111/j.1749-6632.1993.tb32292.x